Colloquium: Dr. Samuel Kakraba
Dr. Samuel Kakraba
Eastern Kentucky University
A Mathematical Graph-Theoretic Model of Single Point Mutations Associated with Sickle Cell Anemia Disease
February 16th, 2022
Mutations in the amino acid sequence of a protein might prevent a protein from assuming the appropriate conformation needed for proper protein functions. Many diseases such as cystic fibrosis and sickle cell anemia disease, COVID-19, and others arise from point mutations in the respective proteins. How mutations, especially point mutation might lead to a global devastating consequence on a protein remains an intellectual mystery hence an improved understanding might offer insight into protein engineering, with potential therapeutic intervention in view.
We present mathematical graph-theoretic modeling interfaced with unsupervised machine learning as a tool to gain meaningful insight
into how single point mutations in a protein might lead to different phenotypes of diseases. Our results suggest this tool should
be added to the toolbox for drug discovery for diseases arising from single point mutations.
Published on February 14, 2022